Liverpool took control of their Uefa Champions League quarterfinal tie against Benfica with a 3-1 win in Portugal while Manchester City will take a slender 1-0 lead into their second-leg against Atletico Madrid after a 1-0 win at the Etihad.
Diego Simeone conceded on Monday that Manchester City have "better" players than Atletico Madrid but said Chelsea's Champions League success last year shows his team can still reach the semi-finals.
Watch as Manchester City duo Pep Guardiola and Bernardo Silva preview their upcoming Champions League quarter-final first leg against Atletico Madrid at the Etihad Stadium on Tuesday evening.
Watch as Liverpool duo Jurgen Klopp and Virgil van Dijk speak to the media ahead of their Champions League quarter-final clash against Benfica in Lisbon on Tuesday evening.
Chelsea face Real Madrid on Wednesday reeling from their heaviest defeat of the season, but Thomas Tuchel's battle-hardened ability to keep his players focused should ensure the Champions League holders are ready for the latest test of their resilience.
Real Madrid's trip to Celta Vigo might once have been seen as a chance to rest and reset but the Clasico capitulation has raised the stakes ahead of next week's Champions League first leg against Chelsea.
Troubled holders Chelsea were drawn against 13-time winners Real Madrid in the quarter-finals of the Champions League on Friday, while Manchester City will take on Atletico Madrid.
Manchester United midfielder Paul Pogba has revealed his house was burgled during his club's Champions League defeat against Atletico Madrid while his children were asleep in their bedroom.
Chelsea coach Thomas Tuchel praised his players for remaining focused amid the uncertainty about the club's future after they progressed Wednesday to the Champions League quarter-finals, where he said they would be "the team nobody wants to play".
Catch up with highlights and reactions from the Champions League as Chelsea sealed their place in the quarter-finals after clinching a 2-1 win over Lille in the return leg at the Stade Pierre-Mauroy.